Section 1 chemical product and company identification. Phenylethyl resorcinol pr has been used widely in the personal care industry as a novel skin lightening ingredient. Top quality phenylethyl resorcinol items standards results appearance white to light brown powder complies purityhplc. About the skin deep ratings ewg provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government.
China sfda is also working hard on compling a new inventory of existing cosmetic ingredient in china iecic to replace the old version issued in 2003. It was recently stated that no additional phases can be found under atmospheric conditions druzbicki, k. If absorbed, may cause symptoms similar to those for ingestion. This msds has been prepared according to the hazard criteria of the controlled products. Relevant data showed that samples were kept stable for at least 90 days. The product was applied over a period of 3 months by 20 women, all of whom also used sunscreen. Global phenylethyl resorcinol market research report 2017. The deadline for this consultation is 31 august, 2012. Phenylethyl resorcinol skincare ingredient loreal paris. Sfda consults on approval of phenylethyl resorcinol as a. It is produced by sulfonating benzene with fuming sulfuric acid and fusing the resulting benzenedisulfonic acid with caustic soda.
Cirs has summarized a few questions in order that symrise regulatory affairs experts might share its experience. Alcohols are classified as primary, secondary, or tertiary according to whether the carbon atom to which the oh group is attached is bonded to one, two, or three other carbon atoms and as monohydric, dihydric, or trihydric according. The improvement of skin whitening of phenylethyl resorcinol by. Sfda consults on approval of phenylethyl resorcinol as a new. On 7 august, 2012, sfda started to seek comments on approval of phenylethyl resorcinol as a cosmetic ingredient. See phenylethyl resorcinol back to ingredient dictionary. Phenylethyl resorcinol is also known as symwhite 377 and was developed by symrise researchers to serve as a lightening and brightening ingredient in skin care products, hair lightening products, and cosmetics. Phenylethyl resorcinol manufacturers, factory, suppliers from china, in case you are intrigued in almost any of our merchandise, remember to will not hesitate to make contact with us and take the initial step to create up a prosperous enterprise romance. Fabrication of carboxylmethyl chitosan nanocarrier via selfassembly for efficient delivery of phenylethyl resorcinol in b16 cells article pdf available in polymers 122. May cause severe gastrointestinal tract irritation with nausea, vomiting and possible burns. Powerful antioxidant activity helps to reduce the inflammatory response and melanocyte stimulation. Phenylethyl resorcinol liposome for cosmetic application was developed to enhance the water solubility and physicol stability. Phenethyl alcohol, or 2phenylethanol, is the organic compound that consists of a phenethyl group c 6 h 5 ch 2 ch 2 group attached to oh.
Selective and reversible inhibition of the synthesis of bacterial deoxyribonucleic acid by phenethyl alcohol. Firstaid measures if breathing is difficult, remove to fresh air and keep at rest in a position comfortable for breathing. Table of contents global phenylethyl resorcinol market research report 2017 1 phenylethyl resorcinol market overview 1. Global phenylethyl resorcinol market 2017 industry research. Enhanced stability of phenylethyl resorcinol in elastic vesicular. Synthetic antioxidant often seen in skinbrightening products. Therefore, the primary objective of this study was to perform a comprehensive characterization of pr. Quizlet flashcards, activities and games help you improve your grades. Our pdf merger allows you to quickly combine multiple pdf files into one single pdf document, in just a few clicks. Phenylethyl resorcinol phenylethyl resorcinol is classified as. However we did show that it was not a concern as described below.
Phenylethyl resorcinol alternative names no information available origin chemisch definition no information available inci function antioxidant the inci function describes solely the purpose of a cosmetic ingredient. Resorcinol has been known to cause hyperemia an excess of blood in a part, itch, dermatitis, edema, and corrosion. In the antityrosinase assay, pr performed higher effective than kojic acid. The selective inhibitory effects of phenethyl alcohol on gramnegative bacteria were confirmed with a variety of species. Though the results from the manufacturer sound quite promising, a skinlightening study from 20 involving phenylethyl resorcinol shows quite moderate results.
Contact of the eye with resorcinol has caused necrosis and corneal perforation. Easily combine multiple files into one pdf document. Phenylethyl resorcinol 41phenylethyl1,3benzenediol pr is a new whitening agent that has been found to have the. Alcohols are classified as primary, secondary, or tertiary according to whether the carbon atom to which the oh group is attached is bonded to one, two, or three other. Characterization and topical delivery of phenylethyl resorcinol.
Preparation and evaluation of phenylethyl resorcinol. Hexylresorcinol is a synthetic ingredient that has been shown to have skinbrightening ability but there is very limited research about it on skin. Ethosome formulations containing phenylethyl resorcinol pr were developed. China sfda is also working hard on compling a new inventory of existing cosmetic ingredient in china iecic to. Symwhite 377 phenyl ethyl resorcinol kingyoung bio technical. For breathing difficulties, oxygen may be necessary. Preparation and evaluation of phenylethyl resorcinol liposome. Surprisingly, there is only limited information describing the physicochemical properties of this active. It is an antioxidant that is considered effective in influencing the formation of pigmentation, and therefore able to lighten the skin. Show this safety data sheet to the doctor in attendance. Albro, gardner mills, the synthesis of two new derivatives of resorcinol and a discussion of their relation to other resorcinol derivatives of therapeutic importance 1930.
According to the clinical results of the manufacturer, 0. All results were converted into relative units of measurement for tyrosinase inhibition efficacy figure 3. Preparation of phenylethyl resorcinol niosomes for cosmetic. The synthesis of two new derivatives of resorcinol and a discussion of their relation to other resorcinol derivatives of therapeutic importance gardner mills albro university of massachusetts amherst follow this and additional works at. At the end of the study, it was determined that the womens uneveness decreased by 43%. Request pdf characterization and topical delivery of phenylethyl resorcinol objective. Phenethyl acetate is the ester resulting from the condensation of acetic acid and phenethyl alcohol. Click on the desired brand to find out the drug price or cost of the drug. A skinlightening and antioxidant active ingredient derived from a molecule that exists naturally in pine tree. They exhibited the physical appearance in terms of particle sizes such that all formulations were in the range of 240. Resorcinol disulfonic acid, ho 2 c 6 h 2 hso 3 2, is a deliquescent mass obtained by the action of sulfuric acid on resorcin. Request pdf development of a nanostructured lipid carrier formulation for.
Phenylethyl resorcinol, the chinese authority was concerned by the potential presence of resorcinol residues. Very little information was found on symwhite 377 or phenylethyl resorcinol that wasnt published by symrise. Preparation of phenylethyl resorcinol niosomes for. Phenylethyl acetate, 11phenylethyl acetate, alphamethyl benzene methanol acetate. The list of cosmetic products below is a selection of the most requested cosmetics that contain the ingredient phenylethyl resorcinol. Resorcinol is also a common scaffold that is found in a class of anticancer agents, some of which luminespib, ganetespib, kw2478, and onalespib were in clinical trials. We are globally recognized as a leading provider of fragrances, flavors and active ingredients as well as aroma chemicals for the perfume, cosmetic, pharmaceutical, food and beverage industries. May cause skin sensitization, an allergic reaction, which becomes evident upon reexposure to this material. It is a colorless liquid with a rose and honey scent and a raspberrylike taste.
Resorcinol 1 foreword concise international chemical assessment documents cicads are published by the international programme on chemical safety ipcs a cooperative programme of the world health organization who, the international labour organization ilo, and the united nations environment programme unep. Proven skin brightening efficacy, reduction of appearance of dark hair and evening of skin tone are the main functions of symwhite plus. Predicted data is generated using the us environmental protection agencys episuite. Global phenylethyl resorcinol market 2017 industry. If inhaled if breathing is difficult, remove to fresh air and keep at rest in a position comfortable for breathing.
Phenylethyl resorcinol pr is a phenolic compound produced from resorcinol. May be absorbed through the skin in harmful amounts. Phenylethyl resorcinol manufacturers, factory, suppliers. Tyrosine is the substrate of tyrosinase and oxidized to ldopa in melanin synthesis.
Characterization and topical delivery of phenylethyl. Phenylethyl resorcinol ingredient for cosmetics formulations find latest products launched and their applications in relevant industry news and technical articles. Sigmaaldrich offers a number of phenylethyl alcohol products. Pea, 2phenylethanol, 2phenylethyl alcohol, benzyl carbinol, pea cas number. Ethosomes of phenylethyl resorcinol as vesicular delivery. The results show that vivinol is significantly more effective at inhibiting tyrosinase production than both kojic acid and phenylethyl resorcinol.
Considered as an obstacle in the quest for beauty, more and more women faced with this disorder are consulting their dermatologist. The phenylethyl resorcinol loaded nanostructured lipid carrier prnlc was. Pr has attracted much attention as a lightening agent in skin care products since it inhibits tyrosinase activity and thus the conversion of tyrosine to ldopa. It occurs widely in nature, being found in a variety of essential oils. Find patient medical information for phenylethyl alcohol bulk on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Like many esters, it is found in a range of fruits and biological products. Sincerity, innovation, rigorousness, and efficiency is the persistent conception of our firm to the longterm to develop together with consumers for mutual reciprocity and mutual advantage for phenylethyl resorcinol, ascorbyl tetraisopalmitate kosmetik, nacetyllcysteine, leonurus japonicus extract, and we are able to enable on the lookout for any products with the customers needs. Resorcinol 108463 5000 u201 no chemical weapons convention.
Generic drug phenylethyl resorcinol available with manufacturer details. Phenylethyl resorcinol pr is a synthetic compound that it has anti tyrosinase property, which tyrosinase is an enzyme substrate for melanin production. How to merge pdfs and combine pdf files adobe acrobat dc. The most compelling research looked at the results of a cream with phenylethyl resorcinol plus three other skinbrightening agents. It does not reveal its actual effects and skin compatibility. It was characterized by a vesicular size of 389 nm, low polydispersity index of 0. Use of the information, documents and data from the echa website is subject to the terms and conditions of this legal notice, and subject to other binding limitations provided for under applicable law, the information, documents and data made available on the echa website may be reproduced, distributed andor used, totally or in part, for noncommercial purposes provided that echa is. We provide custom synthesis and contract manufacturing from milligrams to metric tonnes. It is a colourless liquid that is slightly soluble in water 2 ml100 ml h 2 o, but miscible with most organic solvents. Development of a nanostructured lipid carrier formulation for. Phenylethyl resorcinol report by material, application, and geography global forecast to 2021 is a professional and indepth research report on the worlds major regional market conditions, focusing on the main regions north america, europe and asiapacific and the main countries united states, germany, united kingdom, japan, south korea and china. The meta 1,3 isomer is resorcinol also known as resorcin, which forms clear needle crystals used in the production of diazo dyes and plasticizers. Pdf fabrication of carboxylmethyl chitosan nanocarrier.
The synthesis of two new derivatives of resorcinol and a. Phenylethyl alcohol definition of phenylethyl alcohol by. The other two ingredients nivitol and pmlysine were approved in march this year. Pdf ethosomes of phenylethyl resorcinol as vesicular. Symwhite plus is a blend of symwhite 377, bisabolol and pentylene glycol, stabilized in neutral oil. Explore phenylethyl resorcinol, also known as symwhite. Phenylethyl resorcinol can provide antioxidant protection against the oxidative stress of freeradicals. Please login to display the rating of all cosmetics. Ethosomes, transfersomes, invasomes, topical administration. Phenylethyl resorcinol is a highly efficient safe skin lightener.
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